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Journal of Heredity Advance Access originally published online on November 5, 2008
Journal of Heredity 2009 100(3):386-389; doi:10.1093/jhered/esn098
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© The American Genetic Association. 2008. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Brief Communications

Identification of Novel Single Nucleotide Polymorphisms in Promoter III of the Acetyl-CoA Carboxylase-{alpha} Gene in Goats Affecting Milk Production Traits

Signorelli Federica, Napolitano Francesco, De Matteis Giovanna, Scatà Maria Carmela, Catillo Gennaro, Tripaldi Carmela, and Moioli Bianca

From Agricultural Research Council, Via Salaria 31, 00015 Monterotondo, Italy

Address correspondence to Moioli Bianca at the address above, or e-mail: bianca.moioli{at}entecra.it.

Acetyl-CoA carboxylase-{alpha} (ACACA) is the major regulatory enzyme of fatty acid biosynthesis. We have sequenced a fragment of Promoter III of the ovine ACACA gene in 211 goats of 5 breeds. The caprine sequence showed a high nucleotide identity (99%) with the ovine. We have identified 3 novel single nucleotide polymorphisms (SNPs) that fall in the core sequence of putative binding sites of transcription factors and have lower allele frequency than the wild type in all breeds. We evaluated the allele substitution effect of the SNPs on milk traits in the Saanen and the Local Grey breeds. Results from this study show that the mutations are associated with fat yield.

Key Words: acetyl-CoA carboxylase • goat • polymorphisms

Corresponding Editor: James Womack

Received May 20, 2008
Revised July 21, 2008
Accepted October 15, 2008


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