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Journal of Heredity Advance Access originally published online on March 3, 2009
Journal of Heredity 2009 100(4):501-504; doi:10.1093/jhered/esp004
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© The American Genetic Association. 2009. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Brief Communications

Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice

Akira Ishikawa

From the Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Aichi 464-8601, Japan

Address correspondence A. Ishikawa at the address above, or e-mail address: ishikawa{at}agr.nagoya-u.ac.jp.

The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F2 intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis.

Key Words: body weight • heterosis • mice • overdominance • QTL

Corresponding Editor: Susan Lamont

Received October 14, 2008
Revised January 29, 2009
Accepted February 4, 2009


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