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The Journal of Heredity 1928:19(11):481-485
© 1928 The American Genetic Association 19:481-485

research-article

DETECTION OF HETEROZYGOTES WITH X-RAYS

Difference in Strength of Genetic Characters Resulting from Single or Double Genes Shown in Case of Color in the Mouse

ROBERT T. HANCE

The Rockefeller Institute for Medical Research, and The University of Pittsburgh

Abstract

  1. 1. When given a certain exposure ro x-rays the pigmented hair of colored mice falls out and is repleced with uncolored or white hair.
  2. 2. This reaction has been found to be in part a function of the genetic constitution of the rayed mice. The hair of mice pure for pigmentation becomes on the whole darker in color while hybrid mice almost completely lose their original color. This sugests that this character, when determined by two genes, is "stronger" in its resistance to x-rays than a similar character that has been produced by only one gene.
  3. 3. A tentative explanation based on the observed increase of oxidative activity of tyrosinase following x-radiation is suggested.


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