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The Journal of Heredity 1978:69(2):86-90
© 1978 The American Genetic Association 69:86-90

research-article

The genetics of blind—a lethal factor in mice

LUZ S. TEICHER, and ERNST W. CASPARI

The auithors are, respectively, graduate student and professor emeritus in the Department of Biology University of Rochester, Rochester, New York 14627

Abstract

The linkage relationships of the lethal gene blind (Bld) in the mouse were investigated. The gene is located on chromosome 15, between uw and bt. The distance uw-Bld is 28.2 ± 5.1 cM; Bld—bt is 14.9 ± 2.7 cM; and Bld—Ca is 24.6 ± 2.6 cM. Incomplete penetrance and/or reduced viability of Bld/± animals was found when blind animals were crossed to several strains, but the cross female DBA/2J x male blind yielded complete penetrance and specificity. Evidence is presented for the presence of X-linked modifiers affecting the penetrance and possible increased viability of Bld in strain DBA.


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