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The Journal of Heredity 1978:69(5):321-326
© 1978 The American Genetic Association 69:321-326

research-article

Mus musculus × Mus caroli hybrids: mouse mules

JOHN D. WEST, WILLIAM I. FRELS, and VERNE M. CHAPMAN

During the course of this work the authors were affiliated with the Department of Molecular Biology, Roswell Park Memorial Institute, Buffalo, NY 14263. J.W. is now affiliated with the Department of Zoology, South Parks Road, Oxford, OX1 3PS, England

Abstract

Analysis of six enzymes using starch gel electrophoresis indicates that autosomal and X-linked genes of both parental species are expressed normally in M. musculus × M. caroli hybrids. There is no evidence for allelic repression for the four autosomally inherited enzymes. Banding patterns for G6PD and P0K-I indicate that X-chromosome inactivation occurs and that the maternally derived M. musculus X-chromosome is preferentially expressed in the yolk sac. Despite normal genetic expression none of the four adult female hybrids was fertile and the male hybrids tended to be retarded during fetal development. The routine production of fetal M. musculus × M. caroli hybrids, heterozygous for three X-linked genes coding for G6PD, P0K-1, and HPRT, should provide an excellent system for the analysis of X-chromosome expression and an alternative to the mule for studies of hybrid reproduction and development.


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J Rossant and W. Frels
Interspecific chimeras in mammals: successful production of live chimeras between Mus musculus and Mus caroli
Science, April 25, 1980; 208(4442): 419 - 421.
[Abstract] [PDF]


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