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The Journal of Heredity 1979:70(3):181-184
© 1979 The American Genetic Association 70:181-184

research-article

Inheritance of lysozyme deficiency in rabbits

DAVID J. PRIEUR, and VALERIE M. CAMARA

The authors are affiliated with the Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164. They thank Ms. LeeAndra Froseth for her technical assistance

Abstract

The phenotypes of 273 offspring of 56 matings of various genotypes of lysozyme-deficient and normal New Zealand white rabbits were analyzed. It was determined that lysozyme deficiency of rabbits is inherited as an autosomal recessive with complete penetrance. The symbol Id is suggested for the gene for lysozyme deficiency. Further studies on the nature of the condition revealed that the lysozyme deficiency was not due to a lysozyme that was cold labile, or to a lysozyme that was so tightly bound it was unavailable for enzymatic assay, or to a lysozyme with a variant pH optimum. It was demonstrated, how eyer, that the pH profile of the lysozyme remaining in the Id/Id rabbits was different from that found in normal rabbits.


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