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The Journal of Heredity 1979:70(5):354-356
© 1979 The American Genetic Association 70:354-356

other

Genetic analyses of an immunodeficiency in hereditary muscular dystrophic chickens

KIMBERLY KLINE, CYNTHIA J. MORTON, and BOB G. SANDERS

The authors are research associates and professor in the Department of Zoology. University of Texas Austin, Texas 78712

Abstract

The F1 and F2 progeny of the Storrs strain of muscular dystrophic chickens were analyzed for the modes of inheritance of two immunodeficiencies, reduced IgG levels and a suppressed Con A response, and the relationship the immunodeficiencies have to the muscular dystrophic phenotype. The F1 hybrids derived from normal x muscular dystrophic chicken crosses were normal for the muscular dystrophy phenotype and the two immunodeficiency traits. The reduced IgG levels were not observed in the F2 progeny (F1 x F1 so the factors influencing reduced IgG levels in the Storrs strain of muscular dystrophic chickens remain undetermined. F2 data indicated that the suppressed Con A response is inherited as an au tosomal recessive trait. In the F2 progeny, chickens expressing the muscular dystrophy phenotype occurred in significantly reduced numbers (50 percent of the expected). F2 digenic analyses of the muscular dystrophy trait and the suppressed Con A trait revealed a signifi cantly decreased number of chickens in the muscular dystrophy-normal Con A trait category. Selective mortality of these chickens was ruled out, and it is postulated that the muscular dystrophy-normal Con A chickens may have been classified as normal for both traits. It is possible that the locus coding for Con A responsiveness or perhaps other genes contributed by the gene pool in the progeny crosses have ameliorated the expression of the muscular dystrophy phenotype in segregating F2 progeny. Resolution of any relationship between normal immune Con A responsiveness and reduced severity of the muscular dystrophy phenotype awaits the establishment of a


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