The Journal of Heredity 1981:72(2):130-130
© 1981 The American Genetic Association 72:130
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Elevated body zinc in rats with inherited retinal dystrophy
The author is assistant professor in the Division of Environmental and Nutritional Sciences, School of Public Health, University of California, Los Angeles. CA 90024. This project was supported in part by BRSG S07 RR 5442 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health, and by a Fight for Sight grant-in-aid. Fight for Sight, Inc., New York City.
Abstract
Carcass zinc concentrations were determined in Royal College of Surgeon (RCS) rats carrying the gene for retinal dystrophy. Analysis of zinc was undertaken on both mutant RCS (rdy/rdy) and cogenic control RCS (rdy/+) newborn male pups using atomic absorption spectrophotometry. The carcass of mutant rats contained a higher concentration of zinc but not copper. A relationship between the altered zinc concentrations and subsequent retinal degeneration remains to be determined.