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The Journal of Heredity 1981:72(2):134-136
© 1981 The American Genetic Association 72:134-136

other

A null allele at the Mod-1 locus of the mouse

F. M. Johnson, Fred Chasalow, Susan E. Lewis, Lois Barnett, and C.-Y. Lee

F. M. Johnson is a research geneticist with the Laboratory of Biochemical Genetics, and C.-Y. Lee is a research chemist with the Laboratory of Animal Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. F. Chasalow, S. E. Lewis, and L. Barnett are senior biochemist, senior geneticist, and research assistant, respectively, with the Chemistry and Life Sciences Group of the Research Triangle Institute, Research Triangle Park, NC 27709. The authors acknowledge the excellent assistance of A. Morgan, J. McKenzie, P. McDougal, R. Thomas, E. Porter, and the secretarial services of L. Oglesby, T. Erexson, and R. Powell. This work was supported by NIEHS contract N01-ES-0-002 to Research Triangle Institute.

Abstract

A null mutation at the Mod-1 locus in the mouse Is described. The mutation occurred spontaneously in the C57BL/6Jstrain. Individuals homozygous for the mutant allele survive to reproduce, but there appears to be a detrimental sex-associated viability effect in some individuals carrying the mutant gene.


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