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The Journal of Heredity 1981:72(2):87-93
© 1981 The American Genetic Association 72:87-93

research-article

Progressive ankylosis, a new skeletal mutation in the mouse

Hope O. Sweet, and Margaret C. Green

The authors are professional assistant, and senior staff scientist emeritus, respectively, at the Jackson Laboratory, Bar Harbor, Maine 04609. This work was supported by research grants DEB 79-26708 from the National Science Foundation, and ACS CD 34U from the American Cancer Society to the Jackson Laboratory. The authors wish to thank Dr. Dale R. Coman for helpful advice on the pathological effects of the ank mutation. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Reprint requests should be addressed to Hope O. Sweet, The Jackson Laboratory, Bar Harbor, Maine 04649.

Abstract

Progressive ankylosis, ank, a new recessive skeletal mutation causing a noninflammatory joint disease in mice is described. Preliminary observations suggest that three abnormal processes are involved: increased calcification of calcified cartilage and of joint tissues, hyperplasia of the cells and tissues of the joints, and degeneration within and around the tissues, tendons, and ligaments of the joints. The new mutation is closely linked, with about 4 percent recombination, to underwhite on chr 15.


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