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The Journal of Heredity 1982:73(2):109-111
© 1982 The American Genetic Association 73:109-111

research-article

Ascorbate concentration in tissues from normal and buphthalmic rabbits

Richard R. Fox, Kwok-Wai Lam, Randy Lewen, and Pei-fei Lee

Jackson Laboratory Bar Harbor, ME 04609 (RRF) and the Departments of Ophthalmology and Biochemistry, Albany Medical College of Union University Albany, New York 12208 (KWL, RL PFL)

Please address reprint requests to R. R. Fox

Abstract

Previous studies show a progressive lowering of ascorbate concentration in the aqueous humor from rabbits with hereditary buphthalmus, depending on the severity of the buphthalmus. In this study, the ascorbate concentration of different tissues from age-matched adult buphthalmic and control rabbits were analyzed to determine whether a defect of ascorbate transport occurs in a variety of tissues from rabbits with hereditary buphthalmus. Our results showed that ascorbate changes were observed only in ocular tissues.

The lowering of ascorbate concentration occurs only in lens and cornea, which depend on the aqueous humor to deliver ascorbate from the blood. The tissues that derive ascorbate directly from the blood, such as the cillary body-iris and retina of buphthalmic eyes, have normal ascorbate concentration. It has been postulated that ascorbate is oxidized in the cibary body-iris to facilitate its transj across the epithelium. A defect in the buphthalmic eyes to oxidize ascorbate could be the primary cause of lowering ascorbate concentration in the aqueous humor.


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