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The Journal of Heredity 1982:73(3):224-226
© 1982 The American Genetic Association 73:224-226

other

2,4-D induced clastogenicity and elevated rates of sister chromatid exchanges in cultured human lymphocytes

C. Korte, and S. M. Jalal

St. Mary's College Winona, MN 55987 and the University of North Dakota Grand Forks, ND 58202

Abstract

Potential for genetic damage in future generations from such widely used hormonic herbicide as 2,4-D (2,4-dichlorophenoxyacetic acid) is of serious concern. Yet the data, particularly on mammalian systems, continue to be inadequate and inconclusive. An attempt was made in this study to determine the clas-togenic and mutagenic potential of 2,4-D in cultured lymphocytes. Chromosome damage though statistically insignificant occurred at dosages as low as 0.2µg/ml. Chromosome damage was increased at a statistically significant level whenever the concentration was 50 µg/ml or higher. Mutagenicity, based on rates of increase insister chromatid exchanges, was significant at 10 µg/ml or higher concentrations. Statistical testing was based on analysis of variance, Dunnett's multiple comparison tests and linear regressions. It seems imperative therefore to avoid indiscriminate use of 2,4-D, and to test the compound for long-range low-level exposures.


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