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The Journal of Heredity 1982:73(3):236-238
© 1982 The American Genetic Association 73:236-238

other

The clinical significance of pericentric inversion of the human Y chromosome: a rare "third" type of heteromorphism

Ram S. Verma, Jorge Rodriguez, and Harvey Dosik

Divisions of Cytogenctics and Hematology, the Jewish Hospital and Medical Center of Brooklyn. and the Department of Medicine. State University of New York, Downstate Medical Center Brooklyn. NY. 11238

Please address reprint requests to Dr. Verma, Division of Cytogenetics

Abstract

A 28-year-old normal East Indian was found to have a perlcentric inversion of the Y chromosome. Aftar reviewing the literature, it was concluded that an Inverted Y chromosomes does not impede the production of normal sperm and does not predispose to nondisjunction of other chromosomes in the progeny. Thus, the earlier concept of nondisjunction was rejected, and it is suggested that aberrant cases with aneuploldy and an inverted Y are fortuitous. The pericentric inverted Y is inherited from generation to generation and has no clinical significance The prevalence of males with pericentric Y inversion in the general population is approximately 1 per 1000. It is suggested that a periceniric inversion of the Y chromosomes is a rare chromosomal heteromorphism and should be called type III.


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