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The Journal of Heredity 1983:74(1):2-15
© 1983 The American Genetic Association 74:2-15

research-article

Frequency of spontaneous and induced "point" mutations in higher eukaryotes

James V. Neel

University Professor of Human Genetics, University of Michigan Medical School Ann Arbor, MI 48109

Please address reprint requests to Dr. Neel

Abstract

Data are presented on comparative mutation rates in Drosophila, mice, and humans, as derived from the study of both biochemical and morphological traits. There is a notable similarity in these rates, despite the large differences in average generation time, mean body temperature, and number of cell divisions Intervening between fertlllzation of the egg and production of functional gametes. This suggests the evolution of superi or genetic (DNA) repair strategies in (long-lived) humans. Evidence is reviewed that raises the possibility of higher mutation rates in mostly tropical-dwelling, tribal human populations than in temperate-dwelling civilized groups. The data suggesting that humans may be somewhat less sensitive to the genetic effects of radiation than mice are presented, and the question of whether this apparent difference is real or spurious is discussed. Finally, some possible new directions in the study of the mutation-selection balance are presented.


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