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The Journal of Heredity 1984:75(1):15-18
© 1984 The American Genetic Association 75:15-18

research-article

Platelet storage pool disease in hybrid rats

F1 Fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus)

Ethel Tobach, Joseph L. DeSantis, and Marjorie B. Zucker

The American Museum of Natural History Central Park West at 79th Street, New York, NY 10024
the New York University School of Mediciene 550 First Avenue, New York, NY 10016

Abstract

Fawn-hooded rats have a hemorrhagic disorder known as platelet storage pool deficiency. Parent stocks of Fawn-hooded, Long-Evans, and Wistar (DAB) rats and the progeny of their reciprocal crosses were studied for coat color and percentage 14C-Serotonin uptake and secretion by blood platelets. Progeny of Fawn-hooded and Wistar reciprocal crosses were dark- or light-hooded, whereas all reciprocal crosses with the Long-Evans stock were dark-hooded. The light or fawn hood was significantly associated with the reduced serotonin uptake and secretion characteristic of storage pool deficiency.


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