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The Journal of Heredity 1984:75(2):155-156
© 1984 The American Genetic Association 75:155-156

other

Position of late and early replicating human X chromosomes at somatic metaphase

D. Dosik, K. A. Babu, and R. S. Verma

Interfaith Medical Center Brooklyn
SUNY Downstate Medical Center, Brooklyn New York

Please address reprint requests to Dr. Verma, Division of Cytogenetics, Interfaith Medical Center, 555 Prospect Place, Brooklyn, NY 11238

Abstract

The location of late and early replicating human X chromosomes was determined in metaphases obtained from human females using the RBA technique. The late replicating X chromosome was not observed preferentially in a peripheral location. Nevertheless, a consistent pattern was observed in the location of both sex chromosomes from the pooled observations. The distance between the two X chromosomes did not vary significantly (P>0.05) from person to person. The earlier hypothesis that late replicating auto-somes containing genetically less active chromatin are accumulated at the periphery of the nucleus in plant cells was not observed in human somatic cells.


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