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The Journal of Heredity 1984:75(5):414-415
© 1984 The American Genetic Association 75:414-415

other

Genetic polymorphism of ceruloplasmin in the rat

V. Stolc

Department of Pathology, School of Medicine, University of Pittsburgh Pittsburgh, Pennsylvania 15261

Abstract

The genetic heterogeneity of ceruloplasmin in serum was studied in the progeny of the (LEW x BN)F1 x (LEW x BN)F1 rats. The results of the statistical analysis showed that the Hbb and c loci were linked. However, the autosomal Ces gene was not linked to the Hbb or c loci. The Ces gene was expressed in normal Mendelian pattern and had two alleles that manifested a low (Cesl) or high (Cash) level of the enzyme in serum. The Cesl gene was expressed as a dominant in the F1 generation. Two phenotypes CES-H and CES-L were found in the F2 rats; the females in the parental strain and hybrid had higher cetuloplasmin concentration than the male rats.


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