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The Journal of Heredity 1984:75(5):419-420
© 1984 The American Genetic Association 75:419-420

other

Evidence for separate gene loci (Es-1 and Es-Si) controlling serum esterases in rats

H. Nikaldo, J. Hayakawa, Y. Kondo, and J. Yamada

Institute for Experimental Animals, School of Medicine Kanazawa University, 13–1 Takara-machi, Kanazawa 920, Japan
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University Konoe-cho, Sakyo-ku, Kyoto 606, Japan
present address: Safety Research Laboratory, Tanabe Seiyaku Co., Ltd. 3–16–89 Kashima, Yodogawa-ku, Osaka 532, Japan
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University Konoe-cho, Sakyo-ku, Kyoto 606, Japan

Abstract

The presence or absence of the Es-Sl esterase (female specific sex-influenced esterase) In rat sera was reexamined by the zymogram technique using agarosegel electrophoresls. It was found that female rat sera of the BN/Kyo strain, which has been typed as the Es-Si esterase negative, display an esterase migrating between the Es-1A esterase and the Es-2C esterase. Using a specific alloantibody to the esterase, it was shown that this esterase is identical to the Es-Si esterase. Thus, BN rats are the first described inbred rats possessing the Es-Si esterase, as well as the Es-1A esterase. Mating experiments between BN rats and SHR rats confirmed a previous demonstration that the presence or absence of the Es-Si esterase is controlled by a single gene locus closely linked to the Es-2 locus where the Es-1 locus also is linked. A further survey with 39 strains by the present methods revealed that besides two sublines of the BN strain, E3/Han, LOU/Max and PVG/Max strains also possess both the ES-1A esterase and the Es-Si esterase. The results indicate that these esterases are controlled by separate gene loci.


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