The Journal of Heredity 1984:75(6):435-439
© 1984 The American Genetic Association 75:435-439
research-article |
Association of megacolon with a new dominant spotting gene (Dom) in the mouse
Jackson Laboratory, Bar Harbor Maine 04609
Brown University and Miriam Hospital 164 Summit Avenue, Providence, Rhode Island 02906
Please address reprint requests to Priscilla W. Lane, The Jackson Laboratory, Bar Harbor, ME 04609
Abstract
A new semidominant mutation in the mouse is described. In heterozygotes it produces white spotting and a deficiency of myenteric ganglion Cells in the colon and, in homozygotes it is lethal prior to 13 days of gestation. The mutation, called dominant megacolon, symbol Dom, is located on chromosome (chr) 15, 20.6 ± 1.6 units proximal to Ca. Hairy ears, Eh, a semidominant gene also on chr 15 is shown to have a suppressing effect on crossing over in this section of chr 15.
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