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The Journal of Heredity 1984:75(6):468-472
© 1984 The American Genetic Association 75:468-472

research-article

Anorexia, a recessive mutation causing starvation in preweanling mice

Lois J. Maltais, Priscilla W. Lane, and Wesley G. Beamer

Jackson Laboratory Bar Harbor, Maine 04609

Abstract

A new autosomal recessive lethal mutation in mice, anorexia (anx), located close to pallid (pa) on chromosome (chr) 2, is described. Mutant mice are characterized by growth failure, an emaclated appearance, and abnormal behavior including headweaving, body tremors, uncoordinated gait, and hyperactivity during the late preweanling period. Data suggest that the mutant mice are not ingesting the levels of nutrients necessary to sustain life. This mutation may provide an important tool for studying the neurobiology of suckling behavior in the preweanling animal.


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