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The Journal of Heredity 1985:76(1):12-16
© 1985 The American Genetic Association 76:12-16

research-article

Autosomal recessive inheritance of congenital goiter in Afrikander cattle

M. H. Ricketts, K. Schulz, A. van Zyl, A. J. Bester, C. D. Boyd, H. Meinhold, and P. P. van Jaarsveld

Drs. Ricketts, van Zyl, and van Jaarsveld are affiliated with the Iodine Metabolism Research Unit, Department of Pharmacology, University of Stellenbosch Medical School, P.O. Box 63, Tygerberg 7505, South Africa; Dr. Schulz's address is 15 Darlington Rd, Lynnwood Manor, Pretoria 0081, South Africa; Drs. Bester and Boyd are affiliated with the Molecular and Cellular Cardiology Research Unit, Department of Medical Biochemistry, University of Stellenbosch Medical School, P.O. Box 63, Tygerberg 7505, South Africa; and Dr. Meinhold with the Thyroid Research Group, Klinikum Steglitz, Freie Universität Berlin, D-1000 Berlin 45, FRG. The authors wish to thank Professor R. Mornex, Service d'Endocrinologie, H{odot}pital de I'Antiquaille, Lyon, for doing the TSH analyses; Dr. Gilbert Vassart, IRIBHN, Universitè Libre de Bruxelles, for providing the recombinant cDNA clone; Dr. A. Relief, Department of Human Genetics, University of Stellenbosch Medical School, for advice and assistance in the preparation of the manuscript; the head (formerly Professor F. J. van der Merwe and at present Professor W. A. Vosloo) and staff of the Department of Animal Husbandry, Faculty of Agriculture, University of Stellenbosch, for maintaining the cattle and providing valuable assistance; Professor H. A. Louw, Dean of the Faculty of Agriculture, for his interest and support of the breeding project; Kathy Ricketts who typed the manuscript; and Hermie Visser who prepared the illustrations. Please address reprint requests to the senior author.

Abstract

Congenital goiter was reported in a number of herds of Afrikander cattle in the 1950's. Some affected animals were assembled and maintained as a closed herd. Although considerable biochemical research into the nature of the disease has been conducted, no definitive report has described the mode of inheritance of the defect. This paper presents the results of breeding studies that indicate the defect is inherited as an autosomal recessive. Southern blot analysis of the thyroglobulin gene confirms this finding. In addition, serum levels of TSH (thyroid stimulating hormone, thyrotropin), T3 (3,4,3'-tri-iodothyronine), T4 (thyroxine), rT3 (3,3',5'-tri-iodothyronine), and DIT (dilodotyrosine) of goitrous animals are compared with normal animals.


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