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The Journal of Heredity 1985:76(1):59-60
© 1985 The American Genetic Association 76:59-60

other

Decreased dopachrome oxidoreductase activity in yellow mice

J. I. Barber, D. Townsend, D. P. Olds, and R. A. King

Dr. Barber, Mr. Olds, and Dr. King are affiliated with the Department of Medicine, Medical School, and Dr. Townsend with the Department of Oral Pathology and Genetics, Dental School, of the University of Minnesota, Minneapolis, MN 55455. This work was supported by NIH grants AM 32407 and GM 22167.

Abstract

Dopachrome oxidoreductase (DCOR) is a newly characterized enzyme in the melanin synthetic pathway, active in the conversion of dopachrome to 5,6-dihydroxyindole. DCOR and tyrosinase activity were measured in skin anagen hairbulbs from lethal yellow (Ay/a), sienna yellow (Asy/a) and recessive yellow (e/e) mice with and without treatment with melanocyte-stimulating hormone (MSH). DCOR activity was low (Asy/a) or absent (Ay/a, e/e) In yellow mice without MSH treatment and increased dramatically in the lethal and sienna yellow mice with MSH. There was no increase in DCOR activity in recessive yellow mice with MSH. Corresponding tyrosinase activity was reduced in lethal yellow and sienna yellow mice without MSH, and increased with MSH. Tyrosinase activity was normal in recessive yellow mice without MSH and did not change with MSH. We conclude that DCOR is an MSH-sensitive enzyme and that DCOR activity is absent in recessive yellow melanocytes. The latter finding suggests that the extension locus may be the DCOR locus.


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