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The Journal of Heredity 1985:76(4):243-246
© 1985 The American Genetic Association 76:243-246

research-article

Linkage of loci affecting a murine liver protein and arylsulfatase B to chromosome 13

R. W. Elliott, W. L. Daniel, B. A. Taylor, and E. K. Novak

Drs. Elliott and Novak are affiliated with the Department of Molecular Biology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263; Dr. Daniel with the Department of Genetics and Development, University of Illinois, 515 Morrill Hall, 505 S. Goodwin Ave., Urbana, Il 61801; and Dr. Taylor with the Jackson Laboratory, Bar Harbor, ME 04609. This work was supported by NIH grant GM-24265 (R.W.E.), NIH grant GM-27707 (W.L.D.), and NIH grant GM-18684 (B.A.T.) from the National Institute of General Medical Sciences. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Please address reprint requests to Dr. Daniel.

Abstract

As-1 is the putative structural locus for murine arylsulfatase B, and Lth - 1 determines the presence or absence of a 35 000 dalton acidic liver protein. As - 1 and Lth - 1 were found to be closely linked using recombinant inbred (RI) strains. Both loci were found to have been cotransferred with the pearl (pe) coat color mutation (chromosome 13) in the B6.C3H pe/pe congenic strain. The linkage relationships between pe, Lth - 1, and As - 1 were further defined in a backcross. On the basis of the RI data, the congenic strain result, and the backcross data, the following genetic distances were estimated: pe—As-1, 7.1 ± 4.0 cM; As - 1-Lth—1, 2.5 ± 1.0 cM; and pe—Lth — 1, <6.9 cM. As - 1 and Lth - 1 are the first biochemically defined loci to be added to the chromosome 13 linkage map.


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