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The Journal of Heredity 1985:76(4):311-312
© 1985 The American Genetic Association 76:311-312

other

Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice

Falzah Ahmed, and John G. M. Shire

The authors are affiliated with the Department of iology, University of Essex, Colchester CO4 3SQ, J.K. They wish to thank Sheila Bareham and David payne for their careful technical assistance. Please address reprint requests to Dr. Shire.

Abstract

Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented llpofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosilty for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofusclnosis even though their melanosomes were more severely affected than those of beige mice.


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