Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gyllensten, U.
Right arrow Articles by Wilson, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gyllensten, U.
Right arrow Articles by Wilson, A. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The Journal of Heredity 1985:76(5):321-324
© 1985 The American Genetic Association 76:321-324

research-article

Maternal inheritance of mitochondrial DNA during backcrossing of two species of mice

Ulf Gyllensten, Dan Wharton, and Allan C. Wilson

Dr. Gyllensten is affiliated with the Department of Biochemistry, the University of California, Berkeley, CA 94720, and the Department of Genetics, the University of Stockholm, S-106 91 Stockhoim, Sweden; Mr. Wharton is affiliated with the New York Zoological Society, Bronx Zoo, Bronx, NY 10460, and the Department of Biological Science, Fordham University, Bronx, NY 10458; Dr. Wilson is affiliated with the Department of Biochemistry, the University of California, Berkeley, CA 94720. This study was supported financially by the National Science Foundation (to A.C.W.) and the National Institutes of Health (to A.C.W.), the National Swedish Research Council (to Nils Ryman, Department of Genetics, University of Stockholm, Sweden), and the Sweden-America Foundation (to U.G.). The authors thank Dr. Russell Higuchi and Mr. Chris Martin for doing the reconstruction experiments with spretus and domesticus mtDNAs, and Dr. Oliver Ryder for valuable suggestions. Drs. Rebecca Cann, Stephen Palumbi, and Ellen Prager kindly reviewed a preliminary version of the paper. Please address reprint requests to Dr. Wilson.

Abstract

As Judged by restriction analysis, mitochondrial DNA shows strictly maternal inheritance during 6–8 generations of backcrossing in both directions between Mus domesticus and Mus spretus. The average number of paternal mitochondrial genomes contributed to the next generation is estimated to be no more than one per thousand maternal mitochondrial genomes contributed. Despite the estimated accumulation of over 2000 mutational differences between M. spretus and M. domesticus mtDNAs since their divergence from a common ancestor, each of these mitochondrial DNAs, whether on a M. spretus or a M. domesticus nuclear background, allows mice to develop with seemingly normal viability and fertility.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J HeredHome page
M. Ingman and U. Gyllensten
Analysis of the Complete Human mtDNA Genome: Methodology and Inferences for Human Evolution
J. Hered., November 1, 2001; 92(6): 454 - 461.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
F. V. Meirelles, V. Bordignon, Y. Watanabe, M. Watanabe, A. Dayan, R. B. Lôbo, J. M. Garcia, and L. C. Smith
Complete Replacement of the Mitochondrial Genotype in a Bos indicus Calf Reconstructed by Nuclear Transfer to a Bos taurus Oocyte
Genetics, May 1, 2001; 158(1): 351 - 356.
[Abstract] [Full Text]

Home page
 GeneticsHome page
K. Takeda, S. Takahashi, A. Onishi, H. Hanada, and H. Imai
Replicative Advantage and Tissue-Specific Segregation of RR Mitochondrial DNA Between C57BL/6 and RR Heteroplasmic Mice
Genetics, June 1, 2000; 155(2): 777 - 783.
[Abstract] [Full Text]

Home page
 GeneticsHome page
F. V. Meirelles and L. C. Smith
Mitochondrial Genotype Segregation During Preimplantation Development in Mouse Heteroplasmic Embryos
Genetics, February 1, 1998; 148(2): 877 - 884.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.