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The Journal of Heredity 1985:76(5):341-344
© 1985 The American Genetic Association 76:341-344

research-article

Meiotic nondisjunction and translocation segregation in dwarf (dw/dw) and control T (1;13) 7OH heterozygous mice

P. J. J. Wauben-Penris, and F. A. van der Hoeven

The authors are affiliated with the Department of Genetics, Agricultural University, Gen. Foulkesweg 53, 6703 BM Wageningen, The Netherlands.

Abstract

The meiotic behavior of translocation heterozygous T70 (1;13)H/+ male mice with a Snell dwarf (dw/dw) genotype was compared with that of nondwarf T70H/+ controls. A four-fold increase in the nondisjunction frequency of the normal bivalents occurred as a consequence of the dwarf genotype. This increase is identical to that seen in karyologically normal dwarf males. No effect of the dwarf condition on the segregation of the translocation muitivalent could be noted. Thus, translocation heterozygosity does not enhance the meiotic instability caused by the hypopituitary dwarf condition. From a small sample of oocytes from T70H/+ and chromosomally normal dwarf females It is concluded that nondisjunction in females is not increased by the dwarf condition. In general we conclude that animals with higher spontaneous nondisjunction levels are not necessarily more sensitive to factors increasing nondisjunction.


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