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The Journal of Heredity 1985:76(5):393-395
© 1985 The American Genetic Association 76:393-395


other

Heritable syndrome of skeletal defects in a family of Australian shepherd dogs

D. P. Sponenberg, and A. T. Bowling

The authors are affiliated, respectively, with the Division of Pathobiology and Public Practice, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061; and the Serology Laboratory, Department of Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616. They thank the Genetics Committee of the Australian Shepherd Club of America for bringing this family of dogs to their attention. Dogs with these defects can be made available to those interested by contacting the senior author.

Abstract

A syndrome of multiple defects including cleft palate, polydactyly, and often syndactyly, shortened tibia-fibula, brachygnathism and scoliosis lethal to maies is described in a family of Austrailan shepherd dogs. Female pups lack the cleft palate and survive, but may exhibit the other defects to a lesser degree than do males. Litter data suggest that the trait is inherited as an X-linked lethal gene, but the possibility of a sex-influenced autosomal alleie cannot be ruled out. The syndrome may have arisen in conjunction with instability of the merie locus.


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