Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Silver, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Silver, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The Journal of Heredity 1985:76(6):436-440
© 1985 The American Genetic Association 76:436-440

research-article

Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains

Jonathan Silver

The author is affiliated with the Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205. He thanks Dr. David Alling and Dr. Earl Green for helpful discussions and detailed review of this manuscript.

Abstract

Recombinant inbred (RI) strains are extremely useful for genetic mapping. This paper presents a simple method for determining confidence intervals for linkage estimates based on analysis of RI strains. The results show that such confidence intervals are usually large with the currently available numbers of RI strains. Therefore, map positions based only on analysis of RI strains should be interpreted with caution. To facilitate interpretation of linkage data derived from RI strains, a table is presented giving the 95 percent and 99 percent confidence intervals for all possible linkages detected with up to 45 RI strains.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
J. J. Mullins, L. J. Mullins, D. R. Dunbar, W. J. Brammar, K. W. Gross, and S. D. Morley
Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family
Physiol Genomics, December 13, 2006; 28(1): 129 - 140.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. L. Montooth, J. H. Marden, and A. G. Clark
Mapping Determinants of Variation in Energy Metabolism, Respiration and Flight in Drosophila
Genetics, October 1, 2003; 165(2): 623 - 635.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Stacey, G.-W. Chang, S. L. Sanos, L. R. Chittenden, L. Stubbs, S. Gordon, and H.-H. Lin
EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20
J. Biol. Chem., August 2, 2002; 277(32): 29283 - 29293.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. St. Lezin, W. Liu, J.-M. Wang, N. Wang, V. Kren, D. Krenova, A. Musilova, M. Zdobinska, V. Zidek, D. Lau, et al.
Genetic Isolation of a Chromosome 1 Region Affecting Blood Pressure in the Spontaneously Hypertensive Rat
Hypertension, October 1, 1997; 30(4): 854 - 858.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
K. J. Buck, P. Metten, J. K. Belknap, and J. C. Crabbe
Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice
J. Neurosci., May 15, 1997; 17(10): 3946 - 3955.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. Kim, L. Ashworth, E. Branscomb, and L. Stubbs
The Human Homolog of a Mouse-Imprinted Gene, Peg3, Maps to a Zinc Finger Gene-Rich Region of Human Chromosome 19q13.4
Genome Res., May 1, 1997; 7(5): 532 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. G. Tankersley, R. S. Fitzgerald, R. C. Levitt, W. A. Mitzner, S. L. Ewart, and S. R. Kleeberger
Genetic control of differential baseline breathing pattern
J Appl Physiol, March 1, 1997; 82(3): 874 - 881.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Malik, V. A. Canfield, M.-C. Beckers, P. Gros, and R. Levenson
Identification of the Mammalian Na,K-ATPase beta 3 Subunit
J. Biol. Chem., September 13, 1996; 271(37): 22754 - 22758.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Avraham, R. London, Y. Fu, S. Ota, D. Hiregowdara, J. Li, S. Jiang, L. M. Pasztor, R. A. White, J. E. Groopman, et al.
Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain
J. Biol. Chem., November 17, 1995; 270(46): 27742 - 27751.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M Bucan, B G Herrmann, A M Frischauf, V L Bautch, V Bode, L M Silver, G R Martin, and H Lehrach
Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex.
Genes & Dev., June 1, 1987; 1(4): 376 - 385.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
A L Joyner and G R Martin
En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.
Genes & Dev., March 1, 1987; 1(1): 29 - 38.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.