Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by O'Brien, S. J.
Right arrow Articles by Patterson, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Brien, S. J.
Right arrow Articles by Patterson, D. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The Journal of Heredity 1986:77(6):374-378
© 1986 The American Genetic Association 77:374-378

research-article

Chromosomal mapping of beta-globin and albino loci in the domestic cat

A conserved mammalian chromosome group

S. J. O'Brien, M. E. Haskins, C. A. Winkler, W. G. Nash, and D. F. Patterson

Drs. O'Brien, Winkler, and Nash are affiliated with the Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013. Drs. Haskins and Patterson are affiliated with the University of Pennsylvania, The School of Veterinary Medicine, Philadelphia, PA 19104. The authors are grateful to Janice Simonson and Mary Eichelberger for excellent technical assistance and to Drs. A. Nienhuis and W. F. Anderson for providing molecular clones of the human beta-globin locus. Supported in part by a Genetics Center Grant to the University of Pennsylvania, NIHGM 32592 and RR 02512.

Dr. Nash's current address: H&W Cytogenetic Services, Inc., Sterling, VA 22170.

Abstract

Slamese cats are homozygous for the recessive C6 allele of the color (albino) locus. The c locus is shown here by backcross analysis to be linked to the beta-hemoglobin (HBB) locus in the cat at a distance of approximately eight centiMorgans. The HBB locus and, by inference, the c locus were assigned to feline chromosome D1, by analysis of genomic DNAs from a panel of rodent X cat somatic cell hybrids with a molecular clone of the human beta-globin locus. Evolutionary conservation of the syntenic homology of feline chromosome D1 and human chromosome 11 is extensive. Comparison of high resolution G-trypsin-banded preparations of the two chromosomes permitted cytological alignment of the long arm of the conserved chromosomes providing that a minimum of one paracentric inversion is hypothesized. The placement of the albino locus on conserved syntenic groups of several markers (HBB, HRAS, LDHA) In both cat and mouse strongly Indicates the conservative placement of the as yet unmapped human albino locus in the homologous syntenic group on human chromosome 11p.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J HeredHome page
A. Schmidt-Kuntzel, E. Eizirik, S. J. O'Brien, and M. Menotti-Raymond
Tyrosinase and Tyrosinase Related Protein 1 Alleles Specify Domestic Cat Coat Color Phenotypes of the albino and brown Loci
J. Hered., July 1, 2005; 96(4): 289 - 301.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.