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The Journal of Heredity 1987:78(3):143-146
© 1987 The American Genetic Association 78:143-146

research-article

Linkage analysis of the murine interferon alpha locus (lfa) on chromosome 4

E. De Maeyer, and F. Dandoy

Institut Curie, Université de Paris-Sud Båt. 110, 91405 Orsay, France

Abstract

We performed linkage analysis of the murine interferon alpha gene cluster, lfa, with three different marker genes on chromosome 4: the major urinary protein locus (Mup-1), the brown locus (b) and the misty locus (m). The gene order (from centromere) with intervening percent recombination derived from a first three-point cross is Mup-1—13.6 (±3.6)—lfa—7.9 (±2.8)—m and from a second three-point cross Mup-1—1.7 (±1.7)—b—3.5 (±2.4)—lfa. The combined results indicate that the gene order, from the centromere, is Mup-1—b—lfa—m.


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