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The Journal of Heredity 1987:78(6):361-365
© 1987 The American Genetic Association 78:361-365

research-article

New mutation causing hereditary hepatitis in the laboratory rat

M. C. Yoshida, R. Masuda, M. Sasaki, N. Takeichi, H. Kobayashi, K. Dempo, and M. Mori

Chro-mosome Research Unit, Faculty of Science, Hokkaido University Sapporo, Japan
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine Sapporo, Japan
Department of Pathology, Sapporo Medical College Sapporo, Japan

Abstract

A new mutant causing hereditary hepatitis associated with severe jaundica has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response. Genetic tests indicate that at least a single autosomal recessive gene is responsible for the major cause of hepatitis. Furthermore, liver cancer appears in long survived rats after recovery from Jaundice as well as a few asymptomatic rats without jaundice. The LEC rats thus provide an animal model useful for the basic and clinical studies of hepatitis and liver cancer, including their pathogenesis, prevention, and treatment.


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