The Journal of Heredity 1988:79(1):48-50
© 1988 The American Genetic Association 79:48-50
research-article |
Congenital Osteochondrodysplasia with Systemic Subcutaneous Edema (ocd/ocd): A New Lethal Autosomal Recessive Mutant of the Rat
Department of Veterinary Physiology, Nippon Veterinary and Zootechnical College Tokyo
Address reprint requests to Dr. Suzuki, Department of Veterinary Physiology, Nippon Veterinary and Zootechnical College, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan.
Abstract
The inheritance of a new lethal mutant rate showing congenital osteochondrodysplasia with systemic subcutaneous edema (ocd for the gene symbol) was examined by crossings between the carriers and between F1s derived from the carrier x Long–Evans crossing. The ratio of the affected to phenotypically normal was 276:89 in pups derived from the crossings between the carriers and 83:17 in those at the LE-F2 generation derived from the proven carriers of the LE-F1 animals, thus showing that the ratio is 3:1. The female:male ratio was 47:42 in the affected and 133:143 in the phenotypically normal pups, showing the sex ratio is 1:1, irrespective of the affected or phenotypically normal. The ratio of affected: carrier: noncarrier was 26:58:27 in littermates derived from the crossings between the carriers, showing the ratio is 1:2:1. The results fitted well to the hypothesis that the inheritance is a single autosomal recessive trait. Independence of the gene from linkage group I was also revealed, because the ratio of colored to albino was 14:3 and 65:18 in affected and phenotypically normal pups at the LE-F2 generation, respectively, which fitted to the ratio of 3:1.