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The Journal of Heredity 1988:79(3):200-203
© 1988 The American Genetic Association 79:200-203

research-article

Ultrastructural Aspects of the Goiter in cog/cog Mice

A. Mayerhofer, A. G. Amador, W. G. Beamer, and A. Bartke

Department of Physiology, School of Medicine, Southern lllinois University Carbondale
Jackson Laboratory Bar Harbor, Maine

Address reprint requests to Dr. A. Bartke, Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901-6512.

Abstract

Thyroids of congenitally goitrous (cog/cog) mice were studied with light and electron microscopy. The principal alteration in follicular cells was their largely overdistended rough endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously suggested abnormalities of TG synthesis and/or processing in cog/cog mice.


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