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The Journal of Heredity 1990:81(1):43-50
© 1990 The American Genetic Association 81:43-50

research-article

Patchy Fur (Paf), a Semidominant X-Linked Gene Associated with a High Level of X-Y Nondisjunction in Male Mice

P. W. Lane, and M. T. Davisson

From The Jackson Laboratory Bar Harbor, Maine

Address reprint requests to Ms. Lane, The Jackson Laboratory, Bar Harbor, ME 04609

Abstract

Several X-linked mutations that have associated sex chromosomal nondisjunction have been identified in the mouse. We describe a new semidominant X-linked mutation called patchy fur (Paf) that produces an abnormal coat. It maps to the distal end of the murine X chromosome very near the XY pseudoautosomal region. The degree of severity in affected mice is hemizygous males > homozygous females > heterozygous females. An unusual feature of Paf is that either the mutation itself or an inseparable chromosomal abnormality causes delayed disjunction of the X and Y chromosomes at meiotic metaphase I, which in turn results in approximately 19% XO progeny and slightly less than 1% XXY progeny from Pat/Y males. The effect occurs only in male carriers and thus must extend into the proximal end of the XV pairing region.


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