The Journal of Heredity 1990:81(2):151-153
© 1990 The American Genetic Association 81:151-153
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The Mouse Mutation Ulnaless on Chromosome 2
1From The Jackson Laboratory Bar Harbor, Maine
2the Genetics Division, Medical Research Council Radiobiology Unit Chilton, United Kingdom
Address reprint requests to Dr. Davisson, The Jackson Laboratory, Bar Harbor, ME 04609.
Abstract
The dominant skeletal mutation ulnaless (Ul) in the mouse causes extreme reduction of the radius and ulna and deformities of the tibia and fibula. Penetrance appears to be complete, but the homozygote is not known, as heterozygous males do not breed. We report the linkage of the Ul gene on Chromosome 2, 18 cM proximal to pallid (pa), and describe its phenotypic effects.
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C. Peichel, B Prabhakaran, and T. Vogt The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning Development, January 9, 1997; 124(18): 3481 - 3492. [Abstract] [PDF] |
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Y Herault, N Fraudeau, J Zakany, and D Duboule Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes Development, January 9, 1997; 124(18): 3493 - 3500. [Abstract] [PDF] |
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