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The Journal of Heredity 1990:81(2):151-153
© 1990 The American Genetic Association 81:151-153


other

The Mouse Mutation Ulnaless on Chromosome 2

M. T. Davisson1, and B. M. Cattanach2

1From The Jackson Laboratory Bar Harbor, Maine
2the Genetics Division, Medical Research Council Radiobiology Unit Chilton, United Kingdom

Address reprint requests to Dr. Davisson, The Jackson Laboratory, Bar Harbor, ME 04609.

Abstract

The dominant skeletal mutation ulnaless (Ul) in the mouse causes extreme reduction of the radius and ulna and deformities of the tibia and fibula. Penetrance appears to be complete, but the homozygote is not known, as heterozygous males do not breed. We report the linkage of the Ul gene on Chromosome 2, 18 cM proximal to pallid (pa), and describe its phenotypic effects.


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DevelopmentHome page
C. Peichel, B Prabhakaran, and T. Vogt
The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning
Development, January 9, 1997; 124(18): 3481 - 3492.
[Abstract] [PDF]


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DevelopmentHome page
Y Herault, N Fraudeau, J Zakany, and D Duboule
Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes
Development, January 9, 1997; 124(18): 3493 - 3500.
[Abstract] [PDF]



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