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The Journal of Heredity 1990:81(5):388-392
© 1990 The American Genetic Association 81:388-392

research-article

An X-Linked Recessive Mutation Producing Cleft Palate, Crooked Tail, and Polydactyly in Mice

J. Barra

From the Institut Pasteur, Unité de Génétique des Mammifères Paris, France

Address reprint requests to Dr. Barra, Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France.

Abstract

Palate-tail-digits abnormality (ptd) is a new X-linked recessive mutation affecting the morphogenesis of the mouse. It maps proximal to Tabby. Hemizygous males and homozygous females exhibit skeletal malformations of the tail, polydactyly of the hind feet, and in about 60% of the cases a cleft palate. A very high level of postnatal mortality is observed even among the mutants without a cleft palate.


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[Abstract] [Full Text]


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