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The Journal of Heredity 1991:82(5):402-405
© 1991 The American Genetic Association 82:402-405

research-article

Mapping the Mouse Craniofacial Mutation First Arch (Far) to Chromosome 2

D. M. Juriloff, and M. J. Harris

Department of Medical Genetics, University of British Columbia 6174 University Boulevard, Vancouver, B.C. V6T 1Z3 Canada

Address reprint requests to D. M. Juriloff at the address above

Abstract

First arch (Far) is a semidominant mutation that causes severe craniofacial defects in mice. Here we report the results of linkage studies with the chromosome 2 markers nonagouti, pallid, and Ulnaless. Far is loosely linked to nonagouti (24–37 cM), more closely linked to pallid (13–28 cM), and closely linked to Ulnaless (2.3 ± 1.5 cM).The embryological defect in Far mutants is confined to one segmentally-derived region of the head, the anterior first branchial arch. It may therefore be significant that, in mapping near Ulnaless, Far also maps in the vicinity of the Hox-4 gene cluster.


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