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The Journal of Heredity 1991:82(6):503-505
© 1991 The American Genetic Association 82:503-505

research-article

Linkage of the Chicken MHC to the Nucleolus Organizer Region Visualized using Non-isotopic in situ Hybridization

M. Dominguez-Steglich, C. Auffray, and M. Schmid

From the Department of Human Genetics, University of Wiirzburg Germany
The Institute d'Embryologie, CNRS, and the College de France, Nogent-sur-Marne France

Abstract

Linkage of the chicken major histocompatibility complex (B-complex) to the nucleolus organizer regions (NOR) has been confirmed in situ. Nonradioactive hybridization to metaphase chromosomes using a pool of biotinylated cDNA probes for the B-F, B-Lß, and B-G genes of the B-complex gave positive signals on one or a pair of microchromosomes. Subsequent staining with silver nitrate proved these microchromosomes to be the NOR-bearing pair. The value of employing nonisotopic in situ hybridization techniques for mapping of genes and gene complexes, especially when dealing with microchromosomes, is stressed.


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[Abstract] [Full Text]


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