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The Journal of Heredity 1995:86(4):269-273
© 1995 The American Genetic Association 86:269-273

research-article

Efficacy of Marek's Disease Vaccines in Mhc Heterozygous Chickens: Mhc Congenic x Inbred Line F1 Matings

L. D. Bacon, and R. L. Witter

U.S. Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory 3606 East Mount Hope Road, East Lansing, MI 48823

Abstract

The goal of this study is to demonstrate that Mhc (B) heterozygous chickens differ in efficacy of response to several Marek's disease (MD) vaccines. Four types of B2 heterozygotes, in addition to B2B2 homozygotes, were developed by crossing 15.B congenic males to inbred line 71 (B2B2) hens. The five types of F1 chicks were intermingled in isolations and vaccinated with one of four types of MD vaccine before inoculation with the very virulent Md5 strain of MD herpesvirus. The F1 chickens differ in development of protective immunity following MD vaccination from two perspectives. First, chickens of a particular Mhc genotype were protected better by some vaccines than other. Second, individual vaccine preparations protected some Mhc genotypes more effectively. We conclude that some MD vaccines are more appropriate than others for certain B-haplotypes when chickens are heterozygous for the Mhc. The value of using Mhc-congenic x inbred line F1 animals for studies concerning the influence of the Mhc on vaccinal immunity is discussed.


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