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The Journal of Heredity 1996:87(1):48-53
© 1996 The American Genetic Association 87:48-53

research-article

Mutations in the Anopheles gambiae Pink-Eye and White Genes Define Distinct, Tightly Linked Eye-Color Loci

M. Q. Benedict, N. J. Besansky, H. Chang, O. Mukabayire, and F. H. Collins

From the Division of Parasitic Diseases, Centers for Disease Control and Prevention Mailstop F22, 4770 Buford Highway, Chamblee, GA 30341
Department of Biology, Emory University Atlanta, GA 30322. M.Q.B.

Address correspondence to Dr. Benedict at the CDC.

Corresponding Editor: Ross Maclntyre

Abstract

New eye-color mutations were induced in the mosquito Anopheles gambiae by EMS or {gamma}-irradiation treatments. Seven new sex-linked mutations were isolated, five of which were viable and fully fertile. Of those, three were in the previously described pink-eye (p) gene in which two spontaneous mutations have previously been iden tified. Two other mutations, W1 and W2 were in a gene with no extant mutant alleles that we designate the white gene. One of these, W1 is due to a large deletion in the 5' end of the cloned homolog of the D. melanogaster white gene. The pink-eye and white loci are tightly linked with recombination frequencies of 3.5% and 1.1% between W1 or W2 and the spontaneous mutant allele, pw, respectively. Small samples of F2 larvae were examined for intragenic recombination between various al leles, but none was observed in any experiment. The white mutants, but not the pink-eye, exhibit epistasis over the expression of the larval body pigmentation phenotype collarless and pigmentation of the male accessory glands and testis sheath. These pleiotropic effects are similar to those of D. melanogaster white mu tants and also suggest that white is probably identical to the previously described white-eye gene.


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[Abstract] [Full Text] [PDF]


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