| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Journal of Heredity 1996:87(3):175-190
© 1996 The American Genetic Association 87:175-190
research-article |
Phenotypic Analysis of the Dopa decarboxylase Gene Cluster Mutants in Drosophila melanogaster
From the University of Virginia, Department of Biology Charlottesville, VA 22903–2477
Corresponding Editor: Stephen J. O'Brlen
Abstract
Mutations in a majority of the 18 loci of the Dopa decarboxylase (Ddc) gene cluster effect similar morphological defects of the cuticle and/or catecholamine-related abnormalities. Mutations in 14 loci affect cuticle formation, cuticle sclerotization, or cuticle melanization, with mutations in 11 of these same loci (including Ddc and amd) producing melanotic psueudotumors, symptomatic, perhaps, of abnormal catecholamine metabolism. Mutations in seven of the genes perturb catecholamine pool levels during prepupal and pupal development, all of which also form melanotic pseudotumors, suggesting several of these genes may encode proteins involved in catecholamine metabolism. Thus, the Ddc gene cluster represents in higher eukaryotes an unusual example of a large cluster of functionally related genes involved in a common physiological process.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. W. Jordan, T. J. Morgan, and T. F. C. Mackay Quantitative Trait Loci for Locomotor Behavior in Drosophila melanogaster Genetics, September 1, 2006; 174(1): 271 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ren, C. Zhu, H. Lee, and P. N. Adler Gene Expression During Drosophila Wing Morphogenesis and Differentiation Genetics, October 1, 2005; 171(2): 625 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carbone, A. Llopart, M. deAngelis, J. A. Coyne, and T. F. C. Mackay Quantitative Trait Loci Affecting the Difference in Pigmentation Between Drosophila yakuba and D. santomea Genetics, September 1, 2005; 171(1): 211 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Mace, J. C. Pearson, and W. McGinnis An Epidermal Barrier Wound Repair Pathway in Drosophila Is Mediated by grainy head Science, April 15, 2005; 308(5720): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gonzalez, J. M. Ranz, and A. Ruiz Chromosomal Elements Evolve at Different Rates in the Drosophila Genome Genetics, July 1, 2002; 161(3): 1137 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Stathakis, D. Y. Burton, W. E. McIvor, S. Krishnakumar, T. R. F. Wright, and J. M. O'Donnell The Catecholamines up (Catsup) Protein of Drosophila melanogaster Functions as a Negative Regulator of Tyrosine Hydroxylase Activity Genetics, September 1, 1999; 153(1): 361 - 382. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Vie, M. Cigna, R. Toci, and S. Birman Differential Regulation of Drosophila Tyrosine Hydroxylase Isoforms by Dopamine Binding and cAMP-dependent Phosphorylation J. Biol. Chem., June 11, 1999; 274(24): 16788 - 16795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wiellette, K. Harding, K. Mace, M. Ronshaugen, F. Wang, and W McGinnis spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk Development, January 12, 1999; 126(23): 5373 - 5385. [Abstract] [PDF]
|
|
|
|
|
|
A. Prado, I. Canal, and A. Ferrús The Haplolethal Region at the 16F Gene Cluster of Drosophila melanogaster: Structure and Function Genetics, January 1, 1999; 151(1): 163 - 175. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kozlova, G. V. Pokholkova, G. Tzertzinis, J. D. Sutherland, I. F. Zhimulev, and F. C. Kafatos Drosophila Hormone Receptor 38 Functions in Metamorphosis: A Role in Adult Cuticle Formation Genetics, July 1, 1998; 149(3): 1465 - 1475. [Abstract] [Full Text] [PDF]
|
|