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The Journal of Heredity 1997:88(6):499-503
© 1997 The American Genetic Association 88:499-503

research-article

A Comparative Analysis of Mhc DRB3 Polymorphism in the American Bison (Bison bison)

S. Mikko, M. Spencer, B. Morris, S. Stabile, T. Basu, C. Stormont, and L. Andersson

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences BMC, Box 597, S-751 24 Uppsala, Sweden
Stormont Laboratories, Inc. 1237 East Beamer Street, Woodland, California

Address correspondence to S. Mikko at Departrnent of Medical Pharmacology, Uppsala University, BMC, Box 593, S-75124 Uppsata, Sweden

Corresponding Editor: Stephen J. O'Brien

Abstract

The degree of genetic polymorphism at the DRB3 locus in the major histocompatibility complex (Mhc) of the North American bison was investigated by PCR and DNA sequence analysis. Nine different alleles were characterized in a selected sample of 20 animals. The genetic distances between alleles were as large as usually found at highly polymorphic Mhc locl in other species. A comparative analysis of the DRB3 polymorphism in bison and cattle revealed an extensive sharing of sequence motifs. The result cleatly shows a transspecles persistence of DRB3 allelic lineages in the two species. Consequently a significant amount of Mhc polymorphism has been maintained through the population bottleneck that bison experienced in the late nineteenth century. An analysis of the pattern of sequence polymorphism among bison and cattle DRB3 alleles strongly suggested that interallellc recombination has contributed significantly to the generation of allellc diversity at this locus.


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