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The Journal of Heredity 1998:89(1)
© 1998 The American Genetic Association 89:71-78

Linkage analysis of insecticide-resistant acetylcholinesterase in Heliothis virescens

DG Heckel1, PK Bryson2, and TM Brown2

Departments of 1Biological Science and 2Entomology, Clemson University, Clemson, South Carolina 29634, USA

The noctuid moth Heliothis virescens is a significant pest of several crops including cotton, where the predominant control method relies on chemical insecticides. In the 1970s H. virescens became highly resistant to the organophosphorus insecticide methyl parathion. Organophosphorus and carbamate insecticides inhibit the enzyme acetylcholinesterase (AChE) by binding to the active site, and one mechanism of resistance is an altered AChE insensitive to this inhibition. We characterized Acein, an autosomal locus controlling AChE insensitivity in H. virescens, and mapped it to linkage group 2. This is the first linkage assignment for a gene conferring insecticide resistance in a lepidopteran. The apparent translocation of this autosome to the sex chromosome in many species of the family Tortricidae leads to the prediction that if organophosphorus resistance due to target-site insensitivity occurs in these tortricids, it should be sex linked. This prediction is novel because sex-linked insecticide resistance genes are rare among insects.


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