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The Journal of Heredity 1998:89(3)
© 1998 The American Genetic Association 89:238-247

Distortion of allele frequency distributions provides a test for recent population bottlenecks

G Luikart1,*, FW Allendorf1, J-M Cornuet2, and WB Sherwin3

1Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA 2Laboratoire de Modelisation et de Biologie Evolutive, I.N.R.A./U.R.L.B., Montpellier, France 3School of Biological Science, University of New South Wales, Sydney, Australia *Corresponding author e-mail: gluikart@ujf-grenoble.fr.

We use population genetics theory and computer simulations to demonstrate that population bottlenecks cause a characteristic mode-shift distortion in the distribution of allele frequencies at selectively neutral loci. Bottlenecks cause alleles at low frequency (<0.1) to become less abundant than alleles in one or more intermediate allele frequency class (e.g., 0.1-0.2). This distortion is transient and likely to be detectable for only a few dozen generations. Consequently only recent bottlenecks are likely to be detected by tests for distortions in distributions of allele frequencies. We illustrate and evaluate a qualitative graphical method for detecting a bottleneck-induced distortion of allele frequency distributions. The simple novel method requires no information on historical population sizes or levels of genetic variation; it requires only samples of 5 to 20 polymorphic loci and approximately 30 individuals. The graphical method often differentiates between empirical datasets from bottlenecked and nonbottlenecked natural populations. Computer simulations show that the graphical method is likely (P > .80) to detect an allele frequency distortion after a bottleneck of <=20 breeding individuals when 8 to 10 polymorphic microsatellite loci are analyzed.


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