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The Journal of Heredity 1999:90(4)
© 1999 The American Genetic Association 90:472-476

Inheritance and genetic mapping of the Campus syndrome (CPS): a high-frequency tremor disease in pigs

I Tammen1,*, C Schulze2, J Chavez-Moreno3, D Waberski4, D Simon1, and B Harlizius1

1Department of Animal Breeding and Genetics, 2Department of Pathology, 3Clinic for Swine and Small Ruminants, and 4Department for Reproductive Medicine, Hanover School of Veterinary Medicine, D-30559 Hanover, Germany *Corresponding author at: Department of Veterinary Clinical Sciences, University of Sydney, PMB 3, Camden 2570, NSW, Australia. E-mail: itammen@camden.usyd.edu.au

A new progressive tremor disorder called Campus syndrome (CPS) was observed among the progeny of a normal boar of the Pietrain breed in Germany. Extensive backcross experiments indicate that CPS is inherited as an autosomal dominant trait, and the founder boar, Campus, is believed to be a gonadal mosaic. A linkage analysis of 57 animals mapped the CPS gene to a region on porcine chromosome 7 flanked by the markers SW1418 and SW352, which is homologous to a part of human chromosome (HSA) 14. Human dominant distal myopathy type 1 (MPD1) has been mapped to the homologous region of HSA14. As the myopathological findings in MDP1 show striking similarities to CPS, this porcine disorder may serve as an animal model for MPD1.


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