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The Journal of Heredity 1999:90(4)
© 1999 The American Genetic Association 90:477-484

A human genome map of comparative anchor tagged sequences

Z-Q Chen1, JA Lautenberger, LA Lyons, L McKenzie, and SJ O'Brien*

Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA 1Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland, USA *Corresponding author e-mail: obrien@ncifcri.gov

Effective comparative mapping inference utilizing development gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage amps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.


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