Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Reinsch, N.
Right arrow Articles by Averdunk, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reinsch, N.
Right arrow Articles by Averdunk, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The Journal of Heredity 1999:90(6)
© 1999 The American Genetic Association 90:629-634

A QTL for the degree of spotting in cattle shows synteny with the KIT locus on chromosome 6

N Reinsch1,*, H Thomsen1, N Xu1, M Brink1, C Looft1, E Kalm1, GA Brockmann2, S Grupe2, C Kühn2, M Schwerin2, B Leyhe3, S Hiendleder3, G Erhardt3, I Medjugorac4, I Russ4, M Förster4, R Reents5, and G Averdunk6

1Institut für Tierzucht und Tierhaltung der Christian-Albrechts-Universität zu Kiel, D-24098 Kiel, Germany 2Forschungsinstit für die Biologie landwirtschaftlicher Nutziere, Forschungsbereich Molekularbiologie, Dummerstorf, Germany 3Institut für Tierzucht und Haustiergenetik der Justus-Liebig-Universität, Gleßen, Germany 4Institut für Tierzucht der Ludwig-Maximillians-Universität, München, Germany 5Vereinigte Informationssysteme Tierhaltung w.V., Verden/Aller, Germany 6Bayerische Landesantalt für Tierzucht, Grub, Germany *Corresponding author E-mail: nreinsch@tierzucht.uni-kiel.de

The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families. A Bayesian estimation of heritability yielded a posterior mean of 0.88 and a standard error of 0.08. A quantitative trait loci (QTL) scan over all chromosomes covered by 229 microsatellite marker loci (2926 cM) was performed by fitting a multiple marker regression model to 625 observations from the youngest by fitting a multiple marker regression model to 625 observations from the youngest generation in 18 families. On chromosome 6 a QTL for the proportion of white coat with large effects (experiment-wise error probability < .0001) was found and a less important one on chromosome 3 (chromosome-wise error probability < .009). Chromosome 6 is known to harbor the KIT locus (receptor tyrosinase kinase), which is associated with various depigmentation phenotypes in mice, humans, and pigs. Similarity of phenotypic KIT effects in other species and synteny with the reported QTL suggest that KIT is a serious candidate gene for the degree of spotting in cattle. The results are also discussed with respect to resistance to solar radiation, heat stress, and photosensitization.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J HeredHome page
S. Rieder, C. Hagger, G. Obexer-Ruff, T. Leeb, and P.-A. Poncet
Genetic Analysis of White Facial and Leg Markings in the Swiss Franches-Montagnes Horse Breed
J. Hered., March 1, 2008; 99(2): 130 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
M. A. E. van Hagen, J. van der Kolk, M. A. M. Barendse, S. Imholz, P. A. J. Leegwater, B. W. Knol, and B. A. van Oost
Analysis of the Inheritance of White Spotting and the Evaluation of KIT and EDNRB as Spotting Loci in Dutch Boxer Dogs
J. Hered., November 1, 2004; 95(6): 526 - 531.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
S. Hiendleder, H. Thomsen, N. Reinsch, J. Bennewitz, B. Leyhe-Horn, C. Looft, N. Xu, I. Medjugorac, I. Russ, C. Kuhn, et al.
Mapping of QTL for Body Conformation and Behavior in Cattle
J. Hered., November 1, 2003; 94(6): 496 - 506.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.