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The Journal of Heredity 2000:91(2)
© 2000 The American Genetic Association 91:165-168

Brief communication. The Rift Valley complex as a barrier to gene flow for Anopheles gambiae in Kenya: the mtDNA perspective

T Lehmann1,*, CR Blackston1, NJ Besansky2, AA Escalante1, FH Collins2, and WA Hawley1

1Division of Parasitic Diseases, Centers for Disease Control and Prevention, Mailstop F22, 4770 Buford Hwy., Chamblee, GA 30341, USA 2Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA *Corresponding author E-mail: lbt2@cdc.gov.

Descriptions of A. gambiae population structure based on microsatellite loci and mitochondrial DNA (mtDNA) were incongruent. High differentiation of populations was measured across the Rift Valley by microsatellites, but no differentiation was detected based on mtDNA. To resolve this conflict, we compared the old data to new mtDNA data using the same specimen previously genotyped in microsatellite loci. Analysis of a larger number of mtDNA sequences resulted in high and significant differentiation between populations across the Rift Valley. We developed a method to assess whether differentiation across the Rift Valley was generated by pure drift rather than mutation-drift, based on DNA sequence data. Applying this method to the mtDNA data suggested that pure drift was the primary force generating differentiation between the populations across the Rift, while mutation-drift generated differentiation across the continent. Given adequate sample size, mtDNA provided congruent results with microsatellite loci.


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