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The Journal of Heredity 2000:91(3)
© 2000 The American Genetic Association 91:211-214

Gene diversity of chimpanzee ABO blood group genes elucidated from intron 6 sequences

T Kitano1, R Noda1, K Sumiyama1, RE Ferrell2, and N Saitou1,*

1Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima, 411-8540, Japan 2Department of Human Genetics, University of Pittsburgh, Pittsburgh, PN, USA *Corresponding author E-mail: nsaitou@genes.nlg.ac.jp

The human and nonhuman primate ABO blood group gene shows relatively large numbers of nucleotide differences around the exon 7 region. In this study we determined intron 6 sequences for 9 alleles of common chimpanzee and for 3 alleles of bonobo to estimate nucleotide diversities among them. Sequence length polymorphisms are observed in this region as a repeat appears one to five times. From a phylogenetic network of intron 6 sequences of ABO blood group genes for humans, common chimpanzee, and bonobo, parallel substitutions and/or some kinds of convergent events are predicted in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes; these values were 0.219% and 0.208%, respectively.


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