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The Journal of Heredity 2001:92(6)
© 2001 The American Genetic Association 92:454-461

Analysis of the Complete Human mtDNA Genome: Methodology and Inferences for Human Evolution

M. Ingman, and U. Gyllensten

From the Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, Dag Hammarskjldsvg 20, University of Uppsala, S-751 85 Uppsala, Sweden.

Address correspondence to Ulf Gyllensten at the address above or e-mail: ulf.gyllensten{at}genpat.uu.se.

The analysis of mitochondrial DNA (mtDNA) sequences has been a potent tool in our understanding of human evolution. However, almost all studies of human evolution based on mtDNA sequencing have focused on the control region, which constitutes less than 7% of the mitochondrial genome. The rapid development of technology for automated DNA sequencing has made it possible to study the complete mtDNA genomes in large numbers of individuals, opening the field of mitochondrial population genomics. Here we describe a suitable methodology for determining the complete human mitochondrial sequence and the global mtDNA diversity in humans. Also, we discuss the implications of the results with respect to the different hypotheses for the evolution of modern humans.


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